Email #6

Here is an excerpt from an article that gives you the history of hygiene. It's just another reason to take advantage of this opportunity to change the way people think about preventing sickness and disease.

Historical Perspective

For generations, handwashing with soap and water has been
considered a measure of personal hygiene (1). The concept of
cleansing hands with an antiseptic agent probably emerged in the early 19th century. As early as 1822, a French pharmacist demonstrated that solutions containing chlorides of lime or soda could eradicate the foul odors associated with human corpses and that such solutions could be used as disinfectants and antiseptics (2). In a paper published in 1825, this pharmacist stated that physicians and other persons attending patients with contagious diseases would benefit from moistening their hands with a liquid chloride solution (2).

In 1846, Ignaz Semmelweis observed that women whose babies were delivered by students and physicians in the First Clinic at the General Hospital of Vienna consistently had a higher mortality rate than those whose babies were delivered by midwives in the Second Clinic (3). He noted that physicians who went directly from the autopsy suite to the obstetrics ward had a disagreeable odor on their hands despite washing their hands with soap and water upon entering the obstetrics clinic. He postulated that the puerperal fever that affected so many parturient women was
caused by "cadaverous particles" transmitted from the autopsy suite to the obstetrics ward via the hands of students and physicians. Perhaps because of the known deodorizing effect of chlorine compounds, as of May 1847, he insisted that students and physicians clean their hands with a chlorine solution between each patient in the clinic. The maternal mortality rate in the First Clinic subsequently dropped dramatically and remained low for years. This intervention by Semmelweis represents the first evidence indicating that cleansing heavily contaminated hands with an antiseptic agent between patient contacts may reduce health-care--associated transmission of contagious diseases more effectively than handwashing with plain
soap and water.

In 1843, Oliver Wendell Holmes concluded independently that
puerperal fever was spread by the hands of health personnel (1). Although he described measures that could be taken to limit its spread, his recommendations had little impact on obstetric practices at the time. However, as a result of the seminal studies by Semmelweis and Holmes, handwashing gradually became accepted as one of the most important measures for preventing transmission of pathogens in health-care facilities.

In 1961, the U. S. Public Health Service produced a training
film that demonstrated handwashing techniques recommended for use by health-care workers (HCWs) (4). At the time,
recommendations directed that personnel wash their hands with soap and water for 1--2 minutes before and after patient contact. Rinsing hands with an antiseptic agent was believed to be less effective than handwashing and was recommended only in emergencies or in areas where sinks were unavailable.

In 1975 and 1985, formal written guidelines on handwashing
practices in hospitals were published by CDC (5,6). These
guidelines recommended handwashing with non-antimicrobial soap between the majority of patient contacts and washing with antimicrobial soap before and after performing invasive
procedures or caring for patients at high risk. Use of waterless antiseptic agents (e.g., alcohol-based solutions) was recommended only in situations where sinks were not available.

In 1988 and 1995, guidelines for handwashing and hand antisepsis were published by the Association for Professionals in Infection Control (APIC) (7,8). Recommended indications for handwashing were similar to those listed in the CDC guidelines. The 1995 APIC guideline included more detailed discussion of alcohol-based hand rubs and supported their use in more clinical settings than had been recommended in earlier guidelines. In 1995
and 1996, the Healthcare Infection Control Practices Advisory Committee (HICPAC) recommended that either antimicrobial soap or a waterless antiseptic agent be used for cleaning hands upon leaving the rooms of patients with multidrug-resistant pathogens (e.g., vancomycin-resistant enterococci [VRE] and methicillin-resistant Staphylococcus aureus [MRSA]) (9,10). These guidelines also provided recommendations for handwashing and hand antisepsis in other clinical settings, including routine patient care. Although the APIC and HICPAC guidelines have been adopted by the majority of hospitals, adherence of HCWs
to recommended handwashing practices has remained low (11,12).

Guideline for Hand Hygiene in Health-Care Settings

Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force

Prepared by
John M. Boyce, M.D.1
Didier Pittet, M.D.2
1Hospital of Saint Raphael
New Haven, Connecticut
2University of Geneva
Geneva, Switzerland

References
1. Rotter M. Hand washing and hand disinfection [Chapter 87]. In: Mayhall CG, ed. Hospital epidemiology and infection control. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins, 1999.

2. Labarraque AG. Instructions and observations regarding the use of the chlorides of soda and lime. Porter J, ed. [French] New Haven, CT: Baldwin and Treadway, 1829.

3. Semmelweis I. Etiology, concept, and prophylaxis of childbed fever. Carter KC, ed. 1st ed. Madison, WI: The University of Wisconsin Press, 1983.

4. Coppage CM. Hand washing in patient care [Motion picture]. Washington, DC: US Public Health Service, 1961.

5. Steere AC, Mallison GF. Handwashing practices for the
prevention of nosocomial infections. Ann Intern Med 1975;83:683--90.

6. Garner JS, Favero MS. CDC guideline for handwashing and
hospital environmental control, 1985. Infect Control 1986;7:231--43.

7. Larson E. Guideline for use of topical antimicrobial agents. Am J Infect Control 1988;16:253--66.

8. Larson EL, APIC Guidelines Committee. APIC guideline for
handwashing and hand antisepsis in health care settings. Am J Infect Control 1995;23:251--69.

9. Hospital Infection Control Practices Advisory Committee
(HICPAC). Recommendations for preventing the spread of vancomycin resistance. Infect Control Hosp Epidemiol 1995;16:105--13.

10. Garner JS, Hospital Infection Control Practices Advisory
Committee. Guideline for isolation precautions in hospitals. Infect Control Hosp Epidemiol 1996;17:53--80.

11. Pittet D, Mourouga P, Perneger TV, Members of the Infection Control Program. Compliance with handwashing in a teaching hospital. Ann Intern Med 1999;130:126--30.

12. Boyce JM. It is time for action: improving hand hygiene
in hospitals. Ann Intern Med 1999;130:153--5.

Thanks for reading!

ItKillsGerms.com

www.mypureworks.com/itkillsgermsdotcom

Email #5

The PureWorks opportunity is endless because everyone needs to be clean. Everyone needs what PureWorks has to offer: Doctors, teachers, parents, kids, students, food service employees, nine-to-fivers - anyone who touches any surface with germs. Anyone who touches a surface that can have germs: playground equipment, picnic tables, doorknobs, ATMs, kitchen sinks, office desks, phones, computer keyboards or escalator handrails. The fact is that everyone touches germs so everyone needs those germs eliminated from their hands.

The Center for Disease Control and Prevention says that hand
hygiene is an important way to prevent the spread of germs that may make you and others sick. Most Americans admit they don't wash their hands often enough.

PureWorks makes it easy to keep your hands clean. Once you try it, you'll love it. Then, you'll tell your friends and everyone you care about. And when you do, you'll be rewarded. You receive commission on every product sale!

Thanks again for your time,

ItKillsGerms.com

www.mypureworks.com/itkillsgermsdotcom

Regular news.

Dear Distributors: We have been very involved in looking for ways to make our compensation plan more rewarding and lucrative. Our goal is to have the most rewarding comp plan in the industry. Many of you have found success in both selling product and recruiting distributors. Others have struggled with what to do and how to do it. We recently brought together a cross section of our distributors for an historical meeting and asked them to help us identify ways that we can simplify our existing plan and help more people be successful in accomplishing their financial and business building goals....Their assistance was very beneficial and spurred ideas for enhancements to our plan. Once again you spoke and we listened! This is an exciting time to be involved in PureWorks. We are seeing an increase in momentum among our distributors and customers and the press and media continue to give us a boost by identifying health issues all over the world that require our technology, products and regimen. No company or product line is better prepared to help protect people against the risk of infections caused by pathogenic bacteria such as MRSA and others. There has never been a better time to be involved in PureWorks and take our message and products to the world. We are proud of what we have accomplished and can't wait to show you some of our plans for the near future. At the beginning of 2008, we will be making some important changes designed to provide greater financial rewards to our distributors. Imagine a compensation plan with more simplicity and increased rewards; a plan where you decide what you want and where you want to be....and then best of all, be rewarded for taking action. W h a t I f Y O U h a d..? A more-streamlined commission payout with fewer requirements and enhanced rewards based upon your participation? More rapid growth and fewer rank requirements to access the lucrative bonus pools? An improved plan that is able to reward you for your efforts every month even if you aren't a world class recruiter? A customer program that facilitates sales on a recurring monthly basis and helps build your business every month with a growing Internet customer base? A new rewards program that pays greatly enhanced bonuses to sponsors who recruit and provide quality training and coaching for their new enrollees? A "10-3-10" program designed to create customers and distributors that works every time and builds the proper foundation for your business? And even more exciting enhancements that are in the works? What can you do right now??? If you love the PureWorks products and want to achieve lifelong residual income based on leveraging your work and success in sharing the PureWorks products, then contact every member of your team and ask them to join you in purchasing at least two cases of product for November and December. This will provide you and your team members with the products you need to protect your families, supply customers, and prepare your businesses for the exciting changes in 2008. Please join us as we "rev up" for the New Year, shift into high gear, hit our business goals and make 2008 a year to remember! Sincerly, PureWorks

A little more information.

Scientific Minds At It Again! PureWorks would like to recognize Dr. Walker and Jeff Walker for their recent efforts. They have been working hard in the laboratory to develop new, enhanced methods for testing PureWorks' products. Testing is critically important to insure the continued quality of our products. Their enhanced method is a new and improved approach that is faster and utilizes the newest and best analytical instrumentation available. There are multiple methods for testing "quats" but they are lengthy, expensive and are not as specific for benzethonium chloride. In September, Jeff and Ed traveled to California and presented their new method at the International Meeting of the Association of Official Analytical Chemists (AOAC). The AOAC is the group that validates and approves official test methods that are recognized world wide in legal and regulatory applications. Attendees included scientists from various government agencies including FDA, EPA, CDC and others. Numerous scientists visited their poster and asked about the new method. Increased interest in benzethonium chloride's anti-cancer activity (announced by the National Cancer Institute last year) has spawned new interest in validated analytical methods for this ingredient. Numerous requests were received from other scientists to send them copies of the new method. Jeff and Ed anticipate publishing the new method in a peer-reviewed scientific journal in the near future. The test is performed by HPLC (High Pressure Liquid Chromatograph), an instrument that separates, identifies, and quantifies the benzethonium chloride during the analysis. The new method also simultaneously determines seven other ingredients in the PureWorks products in less than 5 minutes! The new method has been successfully applied to monitor the manufacturing and stability of the PureWorks skin care products. It is essential to run such tests during manufacture of each of product. It is also important to test what happens to each ingredient over time, throughout the shelf-life of each product. During the analysis procedure, the ingredients are separated by a unique solvent system being pumped at high pressure through a special chromatography column. As they exit the column, a highly-sensitive detection system measures their concentration. An example chromatogram of the separation of calibration standards shows the excellent separation. The area under each peak is proportional to its concentration.

PureWorks is proud of this new accomplishment and is excited to share it with the scientific community. We anticipate that this method will become the standard of excellence for testing benzethonium chloride in topical skin care products. We are pleased that Dr. Walker and Jeff continue to improve our analytical technology and enhance our important testing capabilities that support our ongoing quality assurance programs. Congratulations and keep up the good work, guys!